Geïsoleerde longperfusie (ILuP) werd in de jaren 50 voor het eerst beschreven als een methode om hoge concentraties chemotherapie toe te dienen via een gesloten perfusiecircuit. De eerste klinische studies met ILuP suggereren dat deze techniek in de toekomst een bijdrage kan leveren aan de behandeling van patiënten met longmetastasen. In Nederland en België worden momenteel verschillende opties overwogen om het onderzoek voort te zetten.
Bronnen:
- Pastorino U, Buyse M, Friedel G, et al. Long-term results of lung metastasectomy: prognostic analyses based on 5206 cases. J Thorac Cardiovasc Surg. 1997;113:37-49.,Chudgar NP, Brennan MF, Munhoz RR, et al. Pulmonary metastasectomy with therapeutic intent for soft-tissue sarcoma. J Thorac Cardiovasc Surg. 2017;154:319-30.,Creech O, Jr., Krementz ET, Ryan RF, et al. Chemotherapy of cancer: regional perfusion utilizing an extracorporeal circuit. Ann Surg. 1958;148:616-32.,Weksler B, Ng B, Lenert JT, Burt ME. Isolated single-lung perfusion with doxorubicin is pharmacokinetically superior to intravenous injection. Ann Thorac Surg. 1993;56:209-14.,Wang HY, Port JL, Hochwald SN, Burt ME. Revised technique of isolated lung perfusion in the rat. Ann Thorac Surg. 1995;60:211-2.,Hendriks JM, van Schil PE, Eyskens EJ. Modified technique of isolated left lung perfusion in the rat. Eur Surg Res. 1999;31:93-6,Hendriks JM, Van Schil PE, De Boeck G, et al. Isolated lung perfusion with melphalan and tumor necrosis factor for metastatic pulmonary adenocarcinoma. Ann Thorac Surg. 1998;66:1719-25.,Hendriks JM, Van Schil PE, Van Oosterom AA, et al. Isolated lung perfusion with melphalan prolongs survival in a rat model of metastatic pulmonary adenocarcinoma. Eur Surg Res. 1999;31:267-71.,Van Putte BP, Hendriks JM, Romijn S, et al. Combination chemotherapy with gemcitabine with isolated lung perfusion for the treatment of pulmonary metastases. J Thorac Cardiovasc Surg. 2005;130:125-30.,Hendriks JM, Grootenboers MJ, Schramel FM, et al. Isolated lung perfusion with melphalan for resectable lung metastases: a phase I clinical trial. Ann Thorac Surg. 2004;78:1919-26.,Den Hengst WA, Van Putte BP, Hendriks JM, et al. Long-term survival of a phase I clinical trial of isolated lung perfusion with melphalan for resectable lung metastases. Eur J Cardiothorac Surg. 2010;38:621-7.,Beckers PAJ, Versteegh MIM, Van Brakel TJ, et al. Multicenter phase II clinical trial of isolated lung perfusion in patients with lung metastases. Ann Thorac Surg. 2019; 108:167-74.,Van Putte BP, Hendriks JM, Romijn S, et al. Pharmacokinetics after pulmonary artery perfusion with gemcitabine. Ann Thorac Surg. 2003;76:1036-40.,Berzenji L, Van Schil PE. Oligometastatic non-small cell lung cancer: is there a role for locoregional therapy? J Thorac Dis. 2017;9:1814-17.